I am dedicated to helping build the best place to foster a community of scientists and research. In the past, I have done research on molecular and systems evolution.

Research of the Aspuru-Guzik group focuses on three areas of theoretical physical chemistry and its applications: (1) the connections between quantum computation, quantum information and chemistry; (2) theoretical studies of energy and charge transfer in renewable energy materials; (3) methods development for electronic structure theory: first-principles methods, density functional theory, and quantum Monte Carlo.

Revit Technology Corporation ( www.revit.com ) , creator of the first parametric building modeler for architects and building design professionals , today announced it is in the final stages of testing its innovative product with some of the nation's most prominent architectural , engineering and construction firms. The nearly two-dozen firms that are using Revit's groundbreaking technology have all responded positively , noting its ease-of-use and potential to dramatically improve productivity throughout the design cycle.

The O'Shea Lab is interested in deciphering the logic of signaling and transcriptional control, and in understanding the function and mechanism of oscillation of a three-protein circadian clock. Many of our studies make use of three model systems: (1) the Pho pathway, which allows cells to sense and respond to changes in environmental levels of inorganic phosphates; (2) the Hog pathway, involved in responding to osmotic stress; and (3) a circadian clock from a cyanobacterium.

My laboratory has a long history of research on restriction enzymes and their associated DNA methyltransferases. We are interested in developing methods to find new enzymes with novel properties and we use a combination of bioinformatics and biochemical experimentation to probe DNA sequence information from the many microbial genome sequences that are now available. In addition, we are interested in the use of bioinformatics to explore the microbial genomes and use the restriction systems as a paradigm for other general types of genes that are present. One example concerns the DNA methyltransferase genes, which are a specific case of a more general class of mosaic genes that contain a mixture of well-conserved segments and more variable regions. The restriction enzyme genes exemplify the species and/or strain specific genes that typically have no homologs in GenBank. We look for general ways to predict function in such cases. The overall theme of my work is to use bioinformatics to make predictions that can then be tested experimentally in my laboratory. This can then lead to better bioinformatics predictions. We also run REBASE (www.neb.com/rebase), a database of information about restriction enzymes and their associated methyltransferases.

Microfluidics, nanotechnology, magnetics cell biology.